| Description: |
The Structural & Mechanistic Proteomics (STaMP) Laboratory within the Centre for Medicines Discovery (CMD) is fully equipped with the very latest liquid handling and mass spectrometry equipment to facilitate cutting-edge structural proteomics experiments.
How can we help?
- Binding Analysis: HDX-MS characterises protein-ligand interactions, including small molecules, peptides, cell membranes, nucleic acids, and other proteins
- Protein Conformation: HDX-MS reveals conformational changes induced by ligand binding, post-translational modifications, and other factors
- Protein Folding and Polymerisation: HDX-MS helps dissect protein folding/unfolding dynamics
- Drug Discovery: HDX-MS is used in drug development to understand the mechanism of action of small-molecules
- Epitope Mapping: HDX-MS aids in vaccine design and therapeutic antibody development by revealing antibody epitopes
- Biopharmaceuticals: HDX-MS helps characterise protein stability and biologics
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